Disease Information
| CUI | C0030567 |
|---|---|
| Disease Name | Parkinson Disease |
| Synonymous | Parkinson's Disease DISEASE PARKINSON'S Parkinson's disease, NOS Parkinson's disease NOS Parkinsons disease Paralysis Agitans Shaking palsy PALSY, SHAKING PALSY SHAKING SYNDROME PARKINSON'S PARKINSON'S SYNDROME Idiopathic parkinsonism Primary Parkinsonism Parkinsonism, Primary Lewy Body Parkinson Disease Lewy Body Parkinson's Disease Parkinson's Disease, Lewy Body Idiopathic Parkinson Disease Idiopathic Parkinson's disease Parkinson's Disease, Idiopathic Parkinson Disease, Idiopathic PD - Parkinson's disease PARALYSIS AGITANS PARKINSONISM PARALYSIS AGITANS Parkinson's disease NOS (disorder) Parkinson's disease (disorder) Parkinson`s disease |
| Description | A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75) progressive, degenerative disorder of the nervous system characterized by tremors, rigidity, bradykinesia, postural instability, and gait abnormalities; caused by a loss of neurons and a decrease of dopamine in the basal ganglia. |
Gene Information
| CUI | Disease | Gene Symbol | Table Name |
|---|---|---|---|
| C0030567 | Parkinson's disease | HFE | GAD |
