Disease Information
| CUI | C0004153 |
|---|---|
| Disease Name | Atherosclerosis |
| Synonymous | Atheroscleroses Atherosclerosis, NOS Atherosclerosis (& [NOS]) Atheromatosis Atheromatosis, NOS ATHEROSCLEROTIC VASCULAR DISEASE AS - Atherosclerosis Atherosclerosis (morphologic abnormality) |
| Description | age, lifestyle, diet, and gene related degeneration of arteries due to deposition of lipoid plaques (atheromas) on inner arterial walls; main cause of coronary artery disease, a leading cause of death. Thickening and loss of elasticity of the walls of medium and large muscular ARTERIES with lesions in the innermost layer of the artery (ARTERIAL INTIMA). This disease process of atherogenesis includes the retention of cholesterol-rich LIPOPROTEINS and their binding to PROTEOGLYCANS in the arterial intima, generation of proinflammatory molecules that recruit MACROPHAGES to the subendothelial space, formation of FOAM CELLS, and eventual calcification of the arterial wall. These arterial plaques (atheromas) contain CARBOHYDRATES; BLOOD; and CALCIUM. |
Gene Information
| CUI | Disease | Gene Symbol | Table Name |
|---|---|---|---|
| C0004153 | Atherosclerotic Vascular Disease | HFE | GAD |
